THE HUMAN SOX11 GENE - CLONING, CHROMOSOMAL ASSIGNMENT AND TISSUE EXPRESSION

被引：79

作者：

JAY, P

GOZE, C

MARSOLLIER, C

TAVIAUX, S

HARDELIN, JP

KOOPMAN, P

BERTA, P

机构：

[1] CNRS, CRBM, UPR 9008, INSERM, U249, F-34033 MONTPELLIER, FRANCE

[2] UNIV QUEENSLAND, CTR CELLULAR & MOLEC BIOL, BRISBANE, QLD 4072, AUSTRALIA

[3] INST PASTEUR, UNITE GENET MOLEC HUMAINE, CNRS, URA 1968, F-75724 PARIS, FRANCE

来源：

GENOMICS | 1995年 / 29卷 / 02期

关键词：

D O I：

10.1006/geno.1995.9970

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mammalian testis determining gene SRY contains an HMG box-related DNA binding motif. By analogy a family of genes related to SRY in the HMG domain have been called SOX (SRY box-related genes). We have cloned and characterized the human SOX11 gene using the partial cloning of both human and mouse SOX11 genes and mapped it to chromosome 2p25. The SOX11 sequence is strongly conserved with the chicken homologue and is related to SOX4. It contains several putative transcriptional either activator or repressor domains. SOX11 expression pattern is consistent with the hypothesis that this gene is important in the developing nervous system. (C) 1995 Academic Press, Inc.

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页码：541 / 545

页数：5

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