ACTIVATION-ENERGY LANDSCAPE FOR METASTABLE RNA FOLDING

被引：25

作者：

FERNANDEZ, A

SHAKHNOVICH, EI

机构：

[1] MED SCH, DEPT BIOCHEM & MOLEC BIOL, MIAMI, FL 33101 USA

[2] HARVARD UNIV, DEPT CHEM, CAMBRIDGE, MA 02138 USA

来源：

PHYSICAL REVIEW A | 1990年 / 42卷 / 06期

关键词：

D O I：

10.1103/PhysRevA.42.3657

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We consider the relaxation kinetics for folding intermediate structures in random uncorrelated RNA chains. Folding patterns correspond to intrachain secondary structures. We make use of a Monte Carlo simulation that mimics a Markov process to study the refolding dynamics. This is done to obtain the time-dependent behavior of the activation energies. We conclude that the mechanism of relaxation to the equilibrium secondary structure is compatible with the random-energy model as the thermodynamic limit is approached. © 1990 The American Physical Society.

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页码：3657 / 3659

页数：3

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