STUDIES ON CRUDE DRUGS EFFECTIVE ON VISCERAL LARVA MIGRANS .12. NEMATOCIDAL PRINCIPLES IN OAKMOSS ABSOLUTE AND NEMATOCIDAL ACTIVITY OF 2,4-DIHYDROXYBENZOATES

被引：32

作者：

AHAD, AM

GOTO, Y

KIUCHI, F

TSUDA, Y

KONDO, K

SATO, T

机构：

[1] KANAZAWA UNIV, FAC PHARMACEUT SCI, 13-1 TAKARA MACHI, KANAZAWA, ISHIKAWA 920, JAPAN

[2] TAKASAGO INT CORP, OHTA KU, TOKYO 144, JAPAN

[3] KANAZAWA UNIV, SCH MED, KANAZAWA, ISHIKAWA 920, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 04期

关键词：

OAKMOSS ABSOLUTE; EVERNIA-PRUNASTRI; NEMATOCIDAL ACTIVITY; TOXOCARA-CANIS; DIHYDROXYBENZOATE; OCTYL 2,4-DIHYDROXYBENZOATE; STRUCTURE-ACTIVITY RELATIONSHIP;

D O I：

10.1248/cpb.39.1043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nematocidal principles obtained from oakmoss absolute were identified as methyl 2,4-dihydroxy-3,6-dimethylbenzoate (2), ethyl 3-formyl-2,4-dihydroxy-6-methylbenzoate (4), and ethyl 5-chloro-3-formyl-2,4-dihydroxy-6-methylbenzoate (7). In relation to their structures, the nematocidal activity of 2,4-dihydroxybenzoates of methyl to tetradecyl was tested and the strongest activity was found in the octyl ester (minimal lethal concentration = 13-mu-M).

引用

页码：1043 / 1046

页数：4

共 16 条

[1] SEMIEMPIRICAL DERIVATION OF C-13 NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS - HYDROCARBONS, ALCOHOLS, AMINES, KETONES, AND OLEFINS [J].