THE ZINC FINGER PROTEIN GLI TRANSFORMS PRIMARY-CELLS IN COOPERATION WITH ADENOVIRUS E1A

被引：109

作者：

RUPPERT, JM

VOGELSTEIN, B

KINZLER, KW

机构：

[1] JOHNS HOPKINS ONCOL CTR,424 N BOND ST,BALTIMORE,MD 21231

[2] PROGRAM HUMAN GENET,BALTIMORE,MD 21231

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 03期

关键词：

D O I：

10.1128/MCB.11.3.1724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The GLI gene was previously isolated by virtue of its amplification in human glioblastomas. We have now found that GLI expression can result in the in vitro transformation of both primary and secondary rodent cells. When coexpressed with adenovirus E1A, the GLI protein functions analogously to RAS, resulting in the formation of dense foci of cells which are tumorigenic in nude mice.

引用

页码：1724 / 1728

页数：5

共 37 条

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