THE EFFECT OF THYROID-HORMONE AND GLUCOCORTICOIDS ON CARP GROWTH HORMONE-RELEASING FACTOR (GRF)-INDUCED GROWTH-HORMONE (GH) RELEASE IN RAINBOW-TROUT (ONCORHYNCHUS-MYKISS)

被引：22

作者：

LUO, D

MCKEOWN, BA

机构：

[1] SIMON FRASER UNIV,DEPT BIOL SCI,BURNABY V5A 1S6,BC,CANADA

[2] UNIV CALGARY,FAC MED,CTR LIONS SIGHT,CALGARY T2N 4N1,ALBERTA,CANADA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1991年 / 99卷 / 04期

关键词：

D O I：

10.1016/0300-9629(91)90140-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The effect of thyroid hormone and glucocorticoids on carp growth hormone-releasing factor (GRF)-induced growth hormone (GH) secretion was studied on rainbow trout using a dispersed pituitary cell culture system. 2. A combined administration of lower doses (0.01-mu-M) of 3,5,3'-triiodo-L-thyronine (T3) and dexamethasone (Dex) significantly increased spontaneous as well as carp GRF-induced GH release. 3. Lower doses of Dex alone had no effect, and T3 had a marginal effect on GH release. Higher doses of either Dex or T3 potentially reduced GH release. 4. This study indicates an important role of thyroid hormone and/or glucocorticoids in the hypothalamic regulation of GH secretion in fish.

引用

页码：621 / 626

页数：6

共 45 条

[1] PARTIAL HYPOPHYSECTOMY IN TELEOST POECILIA - SEPARATE IDENTITIES OF TELEOSTEAN GROWTH HORMONE AND TELEOSTEAN PROLACTIN-LIKE HORMONE [J].