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EVALUATION OF SUPERCRITICAL FLUID EXTRACTION IN THE PHARMACEUTICAL-INDUSTRY
被引：124
作者：
LARSON, KA
KING, ML
机构：
[1] Merck Sharp & Dohme Research, Lab, Rahway, NJ, USA, Merck Sharp & Dohme Research Lab, Rahway, NJ, USA
关键词：
CHEMICAL REACTIONS - Precipitation - FLUIDS - Extraction - SEPARATION;
D O I：
10.1002/btpr.5420020206
中图分类号：
Q81 [生物工程学（生物技术）];
Q93 [微生物学];
学科分类号：
071005 ;
0836 ;
090102 ;
100705 ;
摘要：
Various steroids precipitate from supercritical CO//2 as very small particles but still retain their crystallinity. This suggests that SCFE in this industry could be utilized as a size reduction method as an alternative to milling. The application of SCFE as a separation technique is demonstrated by the simultaneous extraction and reaction of mevinolin, a metabolite of the fungus Aspergillus terreus.
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页码：73 / 82
页数：10
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