B-LYMPHOCYTE IMMUNOGLOBULIN RECEPTOR DESENSITIZATION IS DOWNSTREAM OF TYROSINE KINASE ACTIVATION

被引：8

作者：

BRUNSWICK, M

JUNE, CH

MOND, JJ

机构：

[1] NMRI,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD 20889

[2] UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814

来源：

CELLULAR IMMUNOLOGY | 1994年 / 156卷 / 01期

关键词：

D O I：

10.1006/cimm.1994.1168

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Resting mature B cells have two classes of immunoglobulin receptors on their surface, IgD and IgM. Activation of a cell by crosslinking one of these receptors leads to homologous and heterologous receptor anergy as judged by the inability to induce a second calcium signal 2 hr after the initial activation step. The mechanism for this anergy is not known. In this report we show that this receptor anergy is downstream of tyrosine kinase activation in that cells pretreated with anti-IgM, when stimulated with anti-IgD, showed tyrosine phosphorylation comparable to that of naive cells, but had no calcium response. (C) 1994 Academic Press, Inc.

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页码：240 / 244

页数：5

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