DIABETES-INSIPIDUS FOR 5 YEARS PRECEDING THE DIAGNOSIS OF HYPOTHALAMIC LANGERHANS CELL HISTIOCYTOSIS

被引:7
作者
CATALINA, PF
GARCIA, MR
DELATORRE, C
PARAMO, C
GARCIAMAYOR, RVG
机构
[1] HOSP GEN VIGO,DIV ENDOCRINE,VIGO,SPAIN
[2] HOSP GEN VIGO,INTERNAL MED SERV,VIGO,SPAIN
[3] HOSP GEN VIGO,PATHOL SERV,VIGO,SPAIN
关键词
DIABETES INSIPIDUS; HYPOTHALAMUS; LANGERHANS CELL HISTIOCYTOSIS; RADIOTHERAPY;
D O I
10.1007/BF03349786
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a case of an adult male with Langerhans cell histiocytosis (LCH), in which the hypothalamic involvement went undetected by radiology and who was diagnosed as having central diabetes insipidus for 5 years before the skin lesions and the hypothalamic mass became evident on a CT scan. The skin lesions spontaneously disappeared but relapsed 12 months later. The hypothalamic mass disappeared six months after low dose radiotherapy with persistance of diabetes insipidus and loss of thirst sensation. We did not observe relapse of the hypothalamic mass within the five years of post-radiotherapy follow-up. Despite the fact that patients with LCH may experience spontaneous remissions and exacerbations in their clinical manifestations, the patient's longterm evolution suggested the mass was cured. We would like to draw the attention of clinicians to the necessity of long-term follow-up in patients initially diagnosed of idiopathic central diabetes insipidus. Furthermore, low dose radiotherapy is a successful treatment for LCH-dependent masses in the hypothalamus; however, normalization or regression of CT abnormalities after radiotherapy did not affect the clinical diabetes insipidus status.
引用
收藏
页码:663 / 666
页数:4
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