ISOLATION AND CHROMOSOMAL ASSIGNMENT OF 100 HIGHLY INFORMATIVE HUMAN SIMPLE SEQUENCE REPEAT POLYMORPHISMS

被引：291

作者：

HUDSON, TJ

ENGELSTEIN, M

LEE, MK

HO, EC

RUBENFIELD, MJ

ADAMS, CP

HOUSMAN, DE

DRACOPOLI, NC

机构：

[1] MIT,CTR GENOME RES,77 MASSACHUSETTS AVE,CAMBRIDGE,MA 02139

[2] MIT,DEPT BIOL,CTR CANC RES,CAMBRIDGE,MA 02139

来源：

GENOMICS | 1992年 / 13卷 / 03期

关键词：

D O I：

10.1016/0888-7543(92)90133-D

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

One hundred highly informative simple sequence repeat (SSR) polymorphisms have been isolated and mapped to specific human chromosomes by somatic cell hybrid analysis. These markers include 97 (CA)n, 2 (AGAT)n, and a single (AACT)n repeat. All the SSRs have heterozygosities > 0.50 and can be amplified using identical PCR conditions. At least one SSR was detected on every chromosome, except for chromosomes 22 and Y. The frequency of (CA)n repeats on each chromosome was proportional to the relative chromosomal length, except for chromosome 15, on which a substantial excess of markers was identified. © 1992.

引用

页码：622 / 629

页数：8

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