DNA STRAND SCISSIONS BY HYDROXAMIC ACIDS-COPPER(II) ION UNDER AEROBIC CONDITIONS

被引：19

作者：

HASHIMOTO, S ^{[1
]}

YAMASHITA, R ^{[1
]}

NAKAMURA, Y ^{[1
]}

机构：

[1] SCI UNIV TOKYO, DEPT BIOL SCI & TECHNOL, NODA, CHIBA 278, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 09期

关键词：

D O I：

10.1246/cl.1992.1639

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbazolyloxyacetohydroxamic acid (1), 9, 9'-decamethylene-bis-carbazolyloxyacetohydroxamic acid (2), benzohydroxamic acid (3) and acetohydroxamic acid (4) without reducing agent under aerobic conditions induced Col El DNA strand scissions with increasing of the activities in the order of 4>3>2>1. Inhibition experiments indicated that hydrogen peroxide and superoxide participated in the reactions, but hydroxyl radical or singlet oxygen did not.

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页码：1639 / 1642

页数：4

相关论文

共 18 条

[1]

BEZKOROVAINY A, 1980, BIOCH NONHEME IRON, P305

[2] DNA-SCISSION AND PROTEIN-SCISSION ACTIVITIES OF ASCORBATE IN THE PRESENCE OF COPPER-ION AND A COPPER-PEPTIDE COMPLEX [J].

CHIOU, SH .

JOURNAL OF BIOCHEMISTRY, 1983, 94 (04) :1259-1267

[3]

ELFORD HL, 1979, CANCER RES, V39, P844

[4] NUCLEASE ACTIVITY OF 1,10-PHENANTHROLINE COPPER-ION - CHEMISTRY OF DEOXYRIBOSE OXIDATION [J].

GOYNE, TE ;

SIGMAN, DS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (09) :2846-2848

[5] CLEAVAGE OF DNA BY COORDINATION-COMPLEXES - SUPEROXIDE FORMATION IN THE OXIDATION OF 1,10-PHENANTHROLINE-CUPROUS COMPLEXES BY OXYGEN - RELEVANCE TO DNA-CLEAVAGE REACTION [J].

GRAHAM, DR ;

MARSHALL, LE ;

REICH, KA ;

SIGMAN, DS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (16) :5419-5421

[6] N-METHYLACETOHYDROXAMIC ACID CATALYZED ESTER HYDROLYSIS [J].

GRUHN, WB ;

BENDER, ML .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (21) :5883-&

[7] NITROSOCARBONYL COMPOUNDS AS INTERMEDIATES IN OXIDATIVE CLEAVAGE OF HYDROXAMIC ACIDS [J].

KIRBY, GW ;

SWEENY, JG .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (19) :704-705

[8] MULTIFUNCTIONAL HYDROLYTIC CATALYZES .8. REMARKABLE ACCELERATION OF HYDROLYSIS OF PARA-NITROPHENYL ACETATE BY MICELLAR BIFUNCTIONAL CATALYSTS [J].

KUNITAKE, T ;

OKAHATA, Y ;

SAKAMOTO, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (24) :7799-7806

[9]

KUNITAKE T, 1975, TETRAHEDRON LETT, P469

[10] NICKEL-MEDIATED SEQUENCE-SPECIFIC OXIDATIVE CLEAVAGE OF DNA BY A DESIGNED METALLOPROTEIN [J].

MACK, DP ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (11) :4604-4606