HISTIOCYTIC HEMOPHAGOCYTOSIS IN A PATIENT WITH KAWASAKI-DISEASE - CHANGES IN THE HYPERCYTOKINAEMIC STATE

被引：27

作者：

OHGA, S

OOSHIMA, A

FUKUSHIGE, J

UEDA, K

机构：

[1] Department of Pacdiatrics, Faculty of Medicine, Kyushu University, Fukuoka, 812, Maidashi 3-1-1, Higashi-ku

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1995年 / 154卷 / 07期

关键词：

KAWASAKI DISEASE; HEMOPHAGOCYTIC SYNDROME; INFLAMMATORY CYTOKINE; INTERFERON-GAMMA;

D O I：

10.1007/BF02074830

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

A 32-month-old Japanese boy exhibited haemophagocytic syndrome (HPS) during the recurrent course of Kawasaki disease. Despite repeated gamma-globulin therapy, he developed cytopenia with marked hepatomegaly and evidence of histiocytic haemophagocytosis in the bone marrow. Serum levels of interferon-gamma and tumour necrosis factor, but not of interleukin-1 beta, increased in parallel with his symptoms. No confirmation was obtained of the association of toxic reactions to the used drugs. No coronary lesions remained as sequelae. Conclusion Cytopenia in Kawasaki disease could herald HPS, and the hypercytokinaemia involved in the two febrile syndromes might be of distinct nature.

引用

页码：539 / 541

页数：3

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