ANTAGONISM OF ASCORBATE AGAINST RADIOPROTECTIVE ACTION OF CYSTEAMINE

被引:13
作者
NASLUND, M [1 ]
EHRENBERG, L [1 ]
DJALALIBEHZAD, G [1 ]
机构
[1] UNIV STOCKHOLM, DEPT RADIOBIOL, WALLENBERG LAB, S-10405 STOCKHOLM, SWEDEN
关键词
D O I
10.1080/09553007614550851
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The interaction of cysteamine (MEA) and ascorbate on the radiosensitivity of Escherichia coli was studied. Cell suspensions were exposed to the drugs for 1 h and irradiated with 42 or 58 krads of 60Co .gamma.-rays between the 30th and 40th min. Ascorbate was found to counteract the radioprotective effect of cysteamine. This probably occurs in conjunction with cellular metabolism and interaction of the drugs with cyclic AMP.
引用
收藏
页码:95 / 99
页数:5
相关论文
共 13 条
[1]   SOME PROPERTIES OF ASCORBATE FREE-RADICAL [J].
BIELSKI, BHJ ;
RICHTER, HW ;
CHAN, PC .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 258 (SEP30) :231-237
[2]   ROLE OF H2O2 IN REVERSIBLE INHIBITION OF RNA-SYNTHESIS BY THIOLS IN ESCHERICHIA-COLI [J].
EHRENBERG, L ;
FEDORCSAK, I ;
HARMSRIN.M ;
NASLUND, M .
ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1974, B 28 (08) :960-962
[3]  
EHRENBERG L, 1974, 5TH INT C RAD RES SE
[4]  
EHRENBERG L, 1973, STIMULATION NEWSLETT, V5, P1
[5]   TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[6]   EFFECT OF ASCORBATE ON RADIOSENSITIZATION OF BACTERIAL CELLS [J].
JOSHI, DS ;
SINGH, BB ;
GOPALAYE.AR ;
EHRENBERG, L .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1973, 24 (06) :631-635
[7]   CHEMICAL RADIATION PROTECTION AND C AMP MECHANISM [J].
LANGENDORFF, H ;
LANGENDORFF, M .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1971, 19 (05) :493-+
[8]  
LEWIN S, 1974, BIOCHEM SOC T, V2, P400
[9]   ROLE OF PEROXIDE IN RADIOPROTECTIVE ACTION OF THIOLS IN E-COLI [J].
NASLUND, M ;
FEDORCSAK, I ;
EHRENBERG, L .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1976, 29 (06) :501-511
[10]  
POLLARD EC, 1966, RADIAT RES S, V6, P194