CEFTIBUTEN - INVITRO ACTIVITY AGAINST RESPIRATORY PATHOGENS, BETA-LACTAMASE STABILITY AND MECHANISM OF ACTION

被引：19

作者：

WISE, R

ANDREWS, JM

ASHBY, JP

THORNBER, D

机构：

[1] Department of Medical Microbiology, Birmingham B18 7QH, Dudley Road Hospital

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1990年 / 26卷 / 02期

关键词：

D O I：

10.1093/jac/26.2.209

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in-vitro activity of ceftibuten against respiratory pathogenic bacteria was studied and compared with that of other oral β-lactam agents. Ceftibuten displayed high activity against Haemophilus influenzae and Branhamella catarrhalis. There was reduced activity against Streptococcus pneumoniae (MIC90 16 mg/l). The protein binding of ceftibuten was 77% and the primary target site PBP 3. A high degree of stability to β-lactamase hydrolysis was observed. © 1990 by The British Society for Antimicrobial Chemotherapy.

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页码：209 / 213

页数：5

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