ENANTIOSELECTIVE SYNTHESIS OF MONOFLUORINATED CHIRAL BUILDING-BLOCKS FROM MALONIC-ACID

被引：31

作者：

IHARA, M ^{[1
]}

KAI, T ^{[1
]}

TANIGUCHI, N ^{[1
]}

FUKUMOTO, K ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,AOBAYAMA,SENDAI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 08期

关键词：

D O I：

10.1039/p19900002357

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the preparation of monofluorinated chiral building blocks has been developed by fluorination of methyl phenylmenthyl monoalkylmalonates using lithium hexamethyldisilazide and 1-fluoro-2,4,6- trimethylpyridinium triflate.

引用

页码：2357 / 2358

页数：2

共 8 条

[1] NEW FLUORINATING REAGENTS .1. THE 1ST ENANTIOSELECTIVE FLUORINATION REACTION
DIFFERDING, E
LANG, RW
[J]. TETRAHEDRON LETTERS, 1988, 29 (47) : 6087 - 6090
[2] FILIPPO JS, 1976, J ORG CHEM, V41, P586
[3] Filler R., 1982, BIOMEDICAL ASPECTS F
[4] ENANTIOSELECTIVE CONSTRUCTION OF A QUATERNARY ASYMMETRIC CARBON CENTER - A VERSATILE SYNTHESIS OF ALPHA-ALKYL ALPHA-AMINO-ACIDS
IHARA, M
TAKAHASHI, M
NIITSUMA, H
TANIGUCHI, N
YASUI, K
FUKUMOTO, K
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (23) : 5413 - 5415
[5] MICROBIAL APPROACH TO THE PRACTICAL MONOFLUORINATED CHIRAL SYNTHONS
KITAZUME, T
SATO, T
KOBAYASHI, T
LIN, JT
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (07) : 1003 - 1006
[6] KITAZUME T, 1984, J FLUORINE CHEM, P1811
[7] N-FLUOROPYRIDINIUM TRIFLATE AND ITS DERIVATIVES - USEFUL FLUORINATING AGENTS
UMEMOTO, T
KAWADA, K
TOMITA, K
[J]. TETRAHEDRON LETTERS, 1986, 27 (37) : 4465 - 4468
[8] ADVANCES IN THE PREPARATION OF BIOLOGICALLY-ACTIVE ORGANOFLUORINE COMPOUNDS
WELCH, JT
[J]. TETRAHEDRON, 1987, 43 (14) : 3123 - 3197

← 1 →