EFFECTS OF FIBRIC ACID-DERIVATIVES ON ACCUMULATION OF ACTIN IN MYOCARDIOCYTES

被引：10

作者：

ARANEGA, A

GONZALEZ, FJ

ARANEGA, AE

MUROS, MA

FERNANDEZ, JE

VELEZ, C

PRADOS, J

ALVAREZ, L

机构：

[1] Basic Cardiovascular Research Section, School of Medicine, University of Granada, Granada

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 1991年 / 33卷 / 01期

关键词：

ACTIN; FIBRIC ACID DERIVATIVE; MYOCARDIOCYTE; CELL CULTURE;

D O I：

10.1016/0167-5273(91)90151-E

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We used sodium dodecylsulphate polyacrylamide gel electrophoresis and immunoblotting to analyze the effects of the fibric acid derivatives bezafibrate, fenofibrate and gemfibrozil on the accumulation of actin in the cytoplasmic and cytoskeletal fraction of cultured myocardiocytes. All three drugs tested modified cellular and subcellular actin in different ways, and the findings are thought to be related with the secondary effect of arrhythmia known to be caused by these drugs. Bezafibrate and gemfibrozil more markedly affected accumulation of actin by myocytes, while fenofibrate interfered less notably with the accumulation of this protein.

引用

页码：47 / 54

页数：8

共 34 条

[1] EFFECTS OF CLOFIBRATE ON SOME MICROSOMAL HYDROXYLATIONS INVOLVED IN FORMATION AND METABOLISM OF BILE-ACIDS IN RAT-LIVER [J].