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HYPOVOLEMIC SHOCK PROMOTES NEUTROPHIL SEQUESTRATION IN LUNGS BY A XANTHINE OXIDASE-RELATED MECHANISM

被引：56
作者：
ANDERSON, BO
MOORE, EE
MOORE, FA
LEFF, JA
TERADA, LS
HARKEN, AH
REPINE, JE
机构：
[1] UNIV COLORADO,HLTH SCI CTR,ELEANOR ROOSEVELT INST CANC RES,4200 E 9TH AVE,DENVER,CO 80262
[2] UNIV COLORADO,DEPT SURG,DENVER,CO 80262
[3] UNIV COLORADO,DEPT MED,DENVER,CO 80262
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 1991年 / 71卷 / 05期
关键词：
OXYGEN RADICALS; VASCULAR INJURY; ISCHEMIA-REPERFUSION; MYELOPEROXIDASE; ADULT RESPIRATORY DISTRESS SYNDROME;
D O I：
10.1152/jappl.1991.71.5.1862
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (approximately 30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham-treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.
引用
收藏
页码：1862 / 1865
页数：4
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