A DISTILLATION METHOD OF PREPARING C-11 LABELED ACETATE FOR ROUTINE CLINICAL USE

被引：21

作者：

ISHIWATA, K ^{[1
]}

ISHII, SI ^{[1
]}

SASAKI, T ^{[1
]}

SENDA, M ^{[1
]}

NOZAKI, T ^{[1
]}

机构：

[1] KITASATO UNIV,FAC HYG SCI,SAGAMIHARA,KANAGAWA 228,JAPAN

来源：

APPLIED RADIATION AND ISOTOPES | 1993年 / 44卷 / 04期

关键词：

D O I：

10.1016/0969-8043(93)90145-Z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A semi-automated synthesis of [1-C-11]acetate for routine clinical studies by positron emission tomography is described. Carboxylation of methylmagnesium chloride in THF with [C-11]CO2 followed by the HCI hydrolysis at low temperature gave [1-C-11]acetic acid, which was distilled with a N2 flow into a NaHCO3 solution. After radioactive and nonradioactive undesirable products were removed by evaporation of the solution to dryness, a sterile and apyrogenic [1-C-11]acetate injection was obtained within 20 min.

引用

页码：761 / 763

页数：3

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