PANCREATIC-CANCER DETECTED BY POSITRON EMISSION TOMOGRAPHY WITH F-18 LABELED DEOXYGLUCOSE - METHOD AND 1ST RESULTS

被引：37

作者：

BARES, R

KLEVER, P

HELLWIG, D

HAUPTMANN, S

FASS, J

HAMBUECHEN, U

ZOPP, L

MUELLER, B

BUELL, U

SCHUMPELICK, V

机构：

[1] Department of Nuclear Medicine, Technical University of Aachen, Aachen, W-5100

[2] Department of Surgery, Technical University of Aachen, Aachen, W-5100

[3] Department of Pathology, Technical University of Aachen, Aachen, W-5100

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1993年 / 14卷 / 07期

关键词：

D O I：

10.1097/00006231-199307000-00013

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In order to evaluate the utility of positron emission tomography (PET) with F-18-labelled deoxyglucose (FDG) for detection of pancreatic cancer 15 patients with pancreatic masses shown by computed tomography were investigated. Static PET scans covering an axial field of view of 15 cm were obtained 45 min after intravenous injection of 150-300 MBq FDG. Focally increased FDG accumulation was present in 12 out of 13 patients with histologically proven adenocarcinoma, in particular in eight of nine lymph node and four of five liver metastases. Scans of two patients with chronic pancreatitis confirmed by surgery revealed a normal FDG distribution. Contrast between tumour and normal tissue depended the metabolic situation prior to FDG injection. High ratios were found in fasting patients whereas no elevated FDG uptake was measured in an insulin-dependent diabetic suffering from carcinoma of the pancreatic head. We conclude that FDG PET might have the potential for detection and even differentiation of pancreatic carcinoma from chronic pancreatitis. Further studies are necessary to substantiate these preliminary findings and to optimize results in diabetic patients.

引用

页码：596 / 601

页数：6

共 13 条

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