SYNTHESIS OF (2S,3S)-[3-2H1]-PROLINE AND (2S,3R)-[2,3-2H2]-PROLINE

被引：18

作者：

DIETERICH, P ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 34期

关键词：

PROLINE; AMINO ACID; PYROGLUTAMATE; ISOTOPIC LABELING; BIOORGANIC;

D O I：

10.1016/S0040-4039(00)73933-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Discovery of conditions for intramolecular trapping of a ketene intermediate has led to an effective synthesis of samples of the amino acid proline which are stereospecifically labelled on the beta-carbon. Since samples of stereospecifically labelled pyroglutamic acid derivatives are prepared in the route, other stereospecifically labelled, biologically important amino acids may be accessed by the synthesis.

引用

页码：5455 / 5458

页数：4

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