ASSEMBLY AND REGULATION OF NADPH OXIDASE AND NITRIC-OXIDE SYNTHASE

被引：101

作者：

BASTIAN, NR ^{[1
]}

HIBBS, JB ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR,SALT LAKE CITY,UT 84148

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 01期

关键词：

D O I：

10.1016/0952-7915(94)90044-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research over the past year has revealed several interesting advances in the biosynthesis of the superoxide anion and nitric oxide. Highlights include the demonstration that the G protein Rac 2 is required for NADPH oxidase activation, the finding that nitric oxide is a feedback inhibitor of nitric oxide synthase isoforms, and the discovery that the continuous catalytic activity of the immune/inflammatory nitric oxide synthase is due to strong calmodulin binding, which is independent of elevated calcium levels. Interferon-gamma primes neutrophils and macrophages for both O-2- and nitric oxide synthesis. However, NADPH oxidase and immune/inflammatory nitric oxide synthase are differentially regulated such that their activities are not simultaneously induced.

引用

页码：131 / 139

页数：9

共 70 条

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