METHOTREXATE ANALOGS .20. REPLACEMENT OF GLUTAMATE BY LONGER-CHAIN AMINO DIACIDS - EFFECTS ON DIHYDROFOLATE-REDUCTASE INHIBITION, CYTO-TOXICITY, AND INVIVO ANTI-TUMOR ACTIVITY

被引：60

作者：

ROSOWSKY, A

FORSCH, R

UREN, J

WICK, M

KUMAR, AA

FREISHEIM, JH

机构：

[1] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT DERMATOL,BOSTON,MA 02115

[3] UNIV CINCINNATI,MED CTR,DEPT BIOL CHEM,CINCINNATI,OH 45267

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1983年 / 26卷 / 12期

关键词：

D O I：

10.1021/jm00366a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：1719 / 1724

页数：6

相关论文

共 56 条

[1] ABELSON HT, 1978, CANCER TREAT REP, V62, P1549
[2] ARONS E, 1975, CANCER RES, V35, P2033
[3] DIRECT PREPARATION OF [N,C-ALPHA]-DIPROTECTED L-ALPHA-AMINOADIPIC ACID FROM L-LYSINE
BALDWIN, JE
HARRISON, P
MURPHY, JA
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (15) : 818 - 819
[4] CHARACTERISTICS OF METHOTREXATE POLYGLUTAMATE FORMATION IN CULTURED HEPATIC CELLS
BALINSKA, M
NIMEC, Z
GALIVAN, J
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1982, 216 (02) : 466 - 476
[5] BALINSKA M, 1981, CANCER RES, V41, P2751
[6] BENOITON L, 1966, BIOCH PREPARATIONS, V11, P80
[7] MILD AND SIMPLE BIOMIMETIC CONVERSION OF AMINES TO CARBONYL-COMPOUNDS
BUCKLEY, TF
RAPOPORT, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (16) : 4446 - 4450
[8] CHABNER BA, 1972, CANCER RES, V32, P2114
[9] ENZYMATIC CLEAVAGE OF METHOTREXATE PROVIDES A METHOD FOR PREVENTION OF DRUG TOXICITY
CHABNER, BA
BERTINO, JR
JOHNS, DG
[J]. NATURE, 1972, 239 (5372) : 395 - &
[10] CURT G, 1982, P AM ASS CANCER RES, V23, P9

← 1 2 3 4 5 6 →