STATE ANALYSIS OF ENDOGENOUS CYANATE ION IN HUMAN PLASMA

被引：20

作者：

KOSHIISHI, I

IMANARI, T

机构：

[1] Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260, 1-33, Yayoi-cho, Chiba-shi

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1990年 / 13卷 / 04期

关键词：

carbamylation; cyanate; homocitrulline; human; plasma proteins; urea; uremia;

D O I：

10.1248/bpb1978.13.254

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyanate ion is continuously produced by spontaneous degradation of urea both in healthy human blood and in blood of patients with uremia on intermittent hemodialysis. The cyanate ion is trapped irreversibly by amino groups as N-carbamyl groups and reversibly by sulfhydryl groups as S-carbamyl groups. Consequently, these reactions keep the cyanate ion levels in plasma extremely low. Plasma proteins may play an important role in the detoxication of cyanate ion. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：254 / 258

页数：5

共 13 条

[1]

BESWICK HT, 1980, EXP EYE RES, V31, P567

[2] THE ISOMERIC TRANSFORMATION OF UREA INTO AMMONIUM CYANATE IN AQUEOUS SOLUTIONS [J].