EMBRYONIC STEM-CELL GRAFTING - THE THERAPY OF THE FUTURE

被引：12

作者：

HOLLANDS, P

机构：

[1] Amerlite Diagnostics Ltd, Aylesbury, Bucks HP2O 1BR, Lincoln Place Green End

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 01期

基金：

英国医学研究理事会;

关键词：

EMBRYONIC HEMATOPOIETIC STEM CELLS; MOUSE; GRAFTING;

D O I：

10.1093/oxfordjournals.humrep.a137262

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The grafting of mouse embryonic haemopoietic cells into deficient recipients is discussed. Donor cells can be obtained from post-implantation mouse embryos in vivo and used to treat X-irradiated or genetically anaemic recipients. The concept of grafting embryonic haemopoietic cells into normal, untreated recipients is also described. Preimplantation mouse blastocysts grown in vitro for 3-4 days can also be used as a source of donor cells. The haematological and immunological aspects of embryonic cell grafting are discussed, followed by a description of current xenotransplantation experiments, including rat into mouse and human into mouse. The review concludes with a discussion of the application of embryonic cell grafting to other tissues and a look into the possible future of this technique.

引用

页码：79 / 84

页数：6

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