LOCALIZATION OF THE GENE FOR INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN TO MOUSE CHROMOSOME 14 NEAR NP-1

被引：16

作者：

DANCIGER, M

KOZAK, CA

NICKERSON, J

REDMOND, TM

FARBER, DB

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,B-237,LOS ANGELES,CA 90024

[2] LOYOLA MARYMOUNT UNIV,LOS ANGELES,CA 90045

[3] NIAID,BETHESDA,MD 20892

[4] NEI,BETHESDA,MD 20892

来源：

GENOMICS | 1990年 / 8卷 / 04期

关键词：

D O I：

10.1016/0888-7543(90)90262-S

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interphotoreceptor retinoid-binding protein (IRBP) is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process. We have used a 900-bp bovine IRBP cDNA fragment to map the corresponding gene, Rbp-3, to mouse chromosome 14 with somatic cell hybrids and have positioned the gene near Np-1 (nucleoside phosphorylase-1) by analysis of the progeny of an intersubspecific backcross. In the human genome, NP maps to human chromosome 14 and RBP3 to human chromosome 10. Thus, these two genes span the putative site of a chromosomal translocation which contributed to divergent karyotype evolution of man and mouse. © 1990.

引用

页码：727 / 731

页数：5

共 43 条

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