BIOLOGICALLY-ACTIVE HEPARIN-LIKE FRAGMENTS WITH A NON-GLYCOSAMINO GLYCAN STRUCTURE .1. A PENTASACCHARIDE CONTAINING A 3-ORTHO-METHYL IDURONIC ACID UNIT

被引：22

作者：

JAURAND, G

BASTEN, J

LEDERMAN, I

VANBOECKEL, CAA

PETITOU, M

机构：

[1] ORGANON INT BV,POB 20,5340 BH OSS,NETHERLANDS

[2] SANOFI RECH,F-94256 GENTILLY,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80583-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe a new approach towards biologically active analogues of glycosaminoglycan fragments where N-sulphates are replaced by O-sulphates and free hydroxyls are substituted by alkyl ethers. Here we demonstrate that introduction of a methyl group at the 3 position of L-iduronic acid residue neither affects the AT III mediated anti-factor Xa activity nor alters the conformational properties of a unique heparin pentasaccharide sequence.

引用

页码：897 / 900

页数：4

共 19 条

[1]

BASTEN, 1992, BIOORG MED CHEM LETT, V2, P901

[2]

BESSODES M, 1988, SYNTHESIS-STUTTGART, P560

[3] CONFORMATIONAL FLEXIBILITY - A NEW CONCEPT FOR EXPLAINING BINDING AND BIOLOGICAL PROPERTIES OF IDURONIC ACID-CONTAINING GLYCOSAMINOGLYCANS [J].