THE EFFECTS OF CHEMOTHERAPY INCLUDING CISPLATIN ON VITAMIN-D METABOLISM

被引：18

作者：

GAO, Y

SHIMIZU, M

YAMADA, S

OZAKI, Y

ASO, T

机构：

[1] TOKYO MED & DENT UNIV,INST MED & DENT ENGN,2-3-10 SURUGADAI,CHIYODA KU,TOKYO 101,JAPAN

[2] TOKYO MED & DENT UNIV,FAC MED,DEPT OBSTET & GYNECOL,TOKYO 113,JAPAN

来源：

ENDOCRINE JOURNAL | 1993年 / 40卷 / 06期

关键词：

1-ALPHA; 25-DIHYDROXYVITAMIN-D(3); CHEMOTHERAPY; CISPLATIN; 1-ALPHA-HYDROXYLASE INHIBITION; FLUOROMETRIC ASSAY;

D O I：

10.1507/endocrj.40.737

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma concentrations of three major vitamin D3 metabolites, 25-hydroxyvitamin D3 (25-OHD3), 24R, 25-dihydroxyvitamin D3 (24,25-(OH)2D3), and 1alpha, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), were determined serially in patients with gynecological malignancies treated by chemotherapy which included cisplatin. While 25-OHD3 and 24,25-(OH)2D3 levels did not change regularly, 1,25-(OH)2D3 decreased significantly (50%) after only one or two courses of the treatment in all cases. In concert with declining 1,25-(OH)2D3, the PTH levels increased two or three times. The results were explained by the impairment by cisplatin of mitochondrial function in proximal tubules in the kidney.

引用

页码：737 / 742

页数：6

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