ANTIGEN-SELECTED T-CELL RECEPTOR DIVERSITY AND SELF-NONSELF HOMOLOGY

被引：108

作者：

CASANOVA, JL

MARYANSKI, JL

机构：

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 08期

关键词：

D O I：

10.1016/0167-5699(93)90140-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies indicate that the T-cell receptor (TCR) repertoire selected by certain antigenic peptide-MHC combinations can be extremely diverse. This is in contrast to earlier studies reporting T-cell responses which were limited in terms of TCR diversity. In this viewpoint, we suggest these variations in TCR diversity may be explained by taking into account the homology between some antigens and self proteins to which T cells are tolerant.

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页码：391 / 394

页数：4

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