CARBON FILAMENTS PROVIDE SUPPORT AND DIRECTIONALITY TO GROWING RAT FETAL SPINAL-CORD EXPLANTS

被引：10

作者：

KHAN, T ^{[1
]}

SAYERS, S ^{[1
]}

GAIK, G ^{[1
]}

DAUZVARDIS, M ^{[1
]}

机构：

[1] LOYOLA UNIV,SCH DENT,DEPT ANAT,MAYWOOD,IL 60153

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 02期

关键词：

Axonal guidance; Biocompatibility; Carbon filament; Microenvironment; Spinal cord explant; Tissue culture;

D O I：

10.1016/0304-3940(90)90619-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinal cord explants obtained from 15 to 17-day-old fetal rats were cultured on bundles of 5-7 μm diameter carbon filaments attached to the bottom of Petri dishes. After a 3 week incubation period, the cultures were fixed and observed by light, scanning, and transmission electron microscopy. Neurites and glial processes were found to be growing both on and between the carbon filaments. The carbon filaments appeared to provide a biocompatible scaffold which promoted adhesion and gave directionality to the growing cell processes. These properties may make carbon filaments a suitable substrate for in vivo implantation into the damaged spinal cord. © 1990.

引用

页码：172 / 176

页数：5

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