INCREASED EXPRESSION OF RETROVIRAL SEQUENCES IN PROGRESSIONALLY ADVANCED RAT PROSTATIC TUMORS

被引：5

作者：

BUSSEMAKERS, MJG ^{[1
]}

VANBOKHOVEN, A ^{[1
]}

VANGRONINGEN, JJM ^{[1
]}

DEBRUYNE, FMJ ^{[1
]}

SCHALKEN, JA ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,6500 HB NIJMEGEN,NETHERLANDS

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80147-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Differential hybridization analysis revealed two cDNA clones, pBUS19 and pBUS30, to be overexpressed in progressionally advanced rat prostatic tumors. Northern blot analysis suggested the clones to be related although no homology in nucleotide sequence could be shown. Isolation and characterization of a pBUS19-related clone, pJG116, and computer-assisted database comparison showed that all three clones could be mapped within a rat-specific endogenous retrovirus. The importance of overexpression of retroviral sequences in advanced prostatic cancer remains unclear. © 1992 Academic Press, Inc.

引用

页码：318 / 324

页数：7

共 21 条

[1] AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303
[2] BUSSEMAKERS MJG, 1991, CANCER RES, V51, P606
[3] NERVE GROWTH-FACTOR REGULATES GENE-EXPRESSION BY SEVERAL DISTINCT MECHANISMS
CHO, KO
SKARNES, WC
MINSK, B
PALMIERI, S
JACKSONGRUSBY, L
WAGNER, JA
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (01) : 135 - 143
[4] ERV3 HUMAN ENDOGENOUS PROVIRUS MESSENGER-RNAS ARE EXPRESSED IN NORMAL AND MALIGNANT-TISSUES AND CELLS, BUT NOT IN CHORIOCARCINOMA TUMOR-CELLS
COHEN, M
KATO, N
LARSSON, E
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1988, 36 (02) : 121 - 128
[5] COURTNEY MG, 1982, CANCER RES, V42, P569
[6] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX
DEVEREUX, J
HAEBERLI, P
SMITHIES, O
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (01) : 387 - 395
[7] DRAGANI TA, 1986, CANCER RES, V46, P1915
[8] EXPRESSION OF TYPE C-RELATED ENDOGENOUS RETROVIRAL SEQUENCES IN HUMAN-COLON TUMORS AND COLON CANCER CELL-LINES
GATTONICELLI, S
KIRSCH, K
KALLED, S
ISSELBACHER, KJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) : 6127 - 6131
[9] ISAACS JT, 1988, PROSTATE, V13, P165
[10] KELLY F, 1982, BIOCHIM BIOPHYS ACTA, V65, P105

← 1 2 3 →