SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-AZABICYCLO[3.2.0]HEPT-2-ENE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS

被引：43

作者：

SINGH, R ^{[1
]}

COOPER, RDG ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,INDIANAPOLIS,IN 46285

来源：

TETRAHEDRON | 1994年 / 50卷 / 42期

关键词：

D O I：

10.1016/S0040-4020(01)89559-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes the synthesis of a series of 6-azabicyclo[3.2.0]hept-2-ene compounds and subsequent results obtained from biological testing, for anti-microbial potency and beta-lactamase inhibition activity. It was determined that a number of compounds possessed some beta-lactamase inhibition efficacy.

引用

页码：12049 / 12064

页数：16

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