ASSOCIATION OF CEREBRAL VASCULITIS WITH A LUPUS ANTICOAGULANT - A CASE WITH BRAIN PATHOLOGY

被引:6
作者
TOUSSIROT, E
FIGARELLABRANGER, D
DISDIER, P
HARLE, JR
WEILLER, PJ
机构
[1] From the department of Internal Medicine, CHU La Timone Marseille
[2] the department of Neuropathology, CHU La Timone Marseille
关键词
LUPUS ANTICOAGULANT; ANTIPHOSPHOLIPID ANTIBODIES; CEREBRAL VASCULITIS; GRANULOMATOUS ANGIITIS OF THE CENTRAL NERVOUS SYSTEM;
D O I
10.1007/BF02243006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The authors report the case of a sixty-five year old woman initially suffering from a thrombocytopenia. The patient was diagnosed as having an autoimmune disease with a lupus anticoagulant, positive antinuclear antibodies and negative anti-DNA antibodies. She then developed an encephalopathy which was fatal despite corticosteroids. Brain pathology revealed a vasculitis with some giant cells, evoking a granulomatous angiitis of the central nervous system. These clinical and biological features suggest a systemic lupus erythematosus with vasculitis or a primary granulomatous angiitis of the central nervous system. Taking into account the clinical manifestations and the presence of a lupus anticoagulant, we finally preferred to identify it as a primary antiphospholid antibodies syndrome, despite absence of anticardiolipin antibodies. Contrary to thrombosis, vasculitis is rarely associated with an anticardiolipin antibody or a lupus anticoagulant. However, vasculitis in the course of primary antiphospholipid antibodies syndrome has been reported previously as in this case report.
引用
收藏
页码:624 / 627
页数:4
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