CONTINUOUS AND MASSIVE INTAKE OF CHITOSAN AFFECTS MINERAL AND FAT-SOLUBLE VITAMIN STATUS IN RATS FED ON A HIGH-FAT DIET

被引：46

作者：

DEUCHI, K

KANAUCHI, O

SHIZUKUISHI, M

KOBAYASHI, E

机构：

[1] Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co., Ltd., Takasaki, Gunma 370-12

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 07期

关键词：

D O I：

10.1271/bbb.59.1211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of continuous and massive intake of chitosan with sodium ascorbate (AsN) on the mineral and the fat-soluble vitamin status in male Sprague-Dawley rats fed on a high-fat diet. The apparent fat digestibility in the chitosan-receiving group was significantly lower than that in the cellulose- or glucosamine-receiving group. Chitosan feeding for 2 weeks caused a decrease in mineral absorption and bone mineral content, and it was necessary to administer twice the amount of Ca in the AIN-76 formula, which was supplemented with AsN, to prevent such a decrease in the bone mineral content, Moreover, the ingestion of chitosan along with AsN led to a marked and rapid decrease in the serum vitamin E level, while such a loss in vitamin E was not observed for rats given glucosamine monomer instead of chitosan.

引用

页码：1211 / 1216

页数：6

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