SIGNIFICANCE OF ANTIBODIES TO CARDIOLIPIN IN UNSELECTED PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICAL AND LABORATORY ASSOCIATIONS

被引：30

作者：

SACHSE, C

LUTHKE, K

HARTUNG, K

FRICKE, M

LIEDVOGEL, B

KALDEN, JR

PETER, HH

LAKOMEK, HJ

HENKEL, E

DEICHER, H

CORVETTA, A

KRAPF, F

LANG, B

PIRNER, K

ROTHER, E

SPECKER, C

STANNATKIESSLING, S

机构：

[1] UNIV KLINIKUM DRESDEN,MED KLIN 3,DRESDEN,GERMANY

[2] ZENT KRANKENHAUS,ZENT LAB,W-2850 BREMERHAVEN,GERMANY

[3] HANNOVER MED SCH,IMMUNOL & TRANSFUS MED ABT,W-3000 HANNOVER,GERMANY

[4] ELIAS MED TECH GMBH,W-7800 FREIBURG,GERMANY

[5] UNIV KLINIKUM ERLANGEN,INST KLIN IMMUNOL & RHEUMATOL,ERLANGEN,GERMANY

[6] UNIV KLINIKUM FREIBURG,RHEUMATOL & KLIN IMMUNOL ABT,FREIBURG,GERMANY

[7] KRANKENHAUS MINDEN,MINDEN,GERMANY

[8] UNIV KLINIKUM ERLANGEN,KLIN IMMUNOL & RHEUMATOL POLIKLIN,ERLANGEN,GERMANY

来源：

RHEUMATOLOGY INTERNATIONAL | 1995年 / 15卷 / 01期

关键词：

ANTICARDIOLIPIN ANTIBODIES; IGG; IGM; SYSTEMIC LUPUS ERYTHEMATOSUS;

D O I：

10.1007/BF00286765

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a multicentre study anticardiolipin antibodies of the IgG and IgM isotypes were measured by a solid phase enzyme immunoassay in 368 patients with systemic lupus erythematosus (SLE) who were not selected on the basis of features of antiphospholipid syndrome. Clinical and laboratory associations of increased levels of anticardiolipin antibodies were evaluated. IgG and IgM antibodies to cardiolipin were documented in 224 (60.9%) and 128 (34.8%) patients, respectively. Regarding the symptoms of antiphospholipid syndrome, elevated amounts of anticardiolipin IgG were significantly associated with spontaneous abortion (P < 0.001), thrombocytopenia (P < 0.01), livedo reticularis (P < 0.01) and a positive direct Coombs test (P < 0.05), but not with thrombosis or central nervous system diseases such as epilepsy and psychosis. IgM antibodies to cardiolipin were associated with a positive direct Coombs test (P < 0.01), but with no other symptom of antiphospholipid syndrome. The predictive values of anticardiolipin antibody determinations in unselected SLE patients were poor for all features of antiphospholipid syndrome because of high proportions of false-positive and false-negative results. As for other manifestations of SLE, positive correlations between raised antibodies to double-stranded DNA and the occurrence of anticardiolipin antibodies of the IgG isotype were observed, and anticardiolipin IgM was negatively associated with nephritis.

引用

页码：23 / 29

页数：7

共 39 条

[1] Tan E.M., Cohen A.S., Fries J.F., Masi A.T., McShane D.J., Rothfield N.F., Schaller J.G., Talal N., Winchester R.J., 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, 25, pp. 1271-1277, (1982)
[2] Cervera R., Khamashta M.A., Font J., Sebastiani G.D., Gil A., Lavilla P., Domenech I., Aydintug A.O., Jedryka-Goral A., DeRamon E., Galeazzi M., Haga H.J., Mathieu A., Houssiau F., Ingelmo M., Hughes G.R.V., Systemic lupus erythematosus: clinical and immunologie patterns of disease expression in a cohort of 1,000 patients, Medicine, 72, pp. 113-124, (1993)
[3] Hughes G.R.V., Systemic lupus erythematosus, Postgrad Med J, 64, pp. 515-521, (1988)
[4] Hughes G.R.V., Thrombosis, abortion, cerebral disease, and the lupus anticoagulant, BMJ, 287, pp. 1088-1089, (1983)
[5] Fort J.G., Cowchock F.S., Abruzzo J.L., Smith J.B., Anticardiolipin antibodies in patients with rheumatic diseases, Arthritis Rheum, 30, pp. 752-760, (1987)
[6] Manoussakis M.N., Gharavi A.E., Drosos A.A., Kitridou R.C., Moutsopoulous H.M., Anticardiolipin antibodies in unselected autoimmune rheumatic disease patients, Clin Immunol Immunopathol, 44, pp. 297-307, (1987)
[7] Manoussakis M.N., Tzioufas A.G., Silis M.P., Pange P.J., Goudevenos J., Moutsopoulous H.M., High prevalence of anticardiolipin and other autoantibodies in a healthy elderly population, Clin Exp Immunol, 69, pp. 557-565, (1987)
[8] Love P.E., Santoro S.A., Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders, Ann Intern Med, 112, pp. 682-698, (1990)
[9] Harris E.N., Gharavi A.E., Boey M.L., Patel B.M., Mackworth-Young C.G., Loizou S.V., Hughes G.R.V., Anti-cardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus, Lancet, 2, pp. 1211-1214, (1983)
[10] Harris E.N., Chan J.K.H., Asherson R.A., Aber V.R., Gharavi A.E., Hughes G.R.V., Thrombosis, recurrent fetal loss, and thrombocytopenia: predictive value of the anticardiolipin antibody test, Arch Intern Med, 146, pp. 2153-2156, (1986)

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