BLOOD-BRAIN BARRIER TO ALBUMIN IN EMBRYONIC NEW BORN AND ADULT RATS

被引：84

作者：

OLSSON, Y

SOURANDER, P

STEINWALL, O

KLATZO, I

机构：

[1] The Neuropathological Laboratory, Department of Pathology I, University of Göteborg

[2] Section on Clinical Neuropathology, Branch of Surgical Neurology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, 20014, Maryland

[3] The Neuropathological Laboratory, Department of Pathology I, University of Göteborg, Göteborg

[4] Neurological Department, University of Göteborg

来源：

ACTA NEUROPATHOLOGICA | 1968年 / 10卷 / 02期

关键词：

Blood-brain barrier; Development of BBB; Fluorescein labeled protein transfer; Fluorescence microscopy; Vascular permeability;

D O I：

10.1007/BF00691305

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A study was made on the permeability of cerebral blood vessels to albumin during development. Fluorescent labeled bovine serum albumin was injected into a tail vein of newborn, young and adult rats and into the umbilical artery of embryos from the fifteenth to the twenty-first day of pregnancy. The distribution of the tracer was ascertained by means of fluorescence microscopy. In the brains of the embryos and postnatal rats the fluorescent albumin was strictly confined to the lumen of the blood vessels, while considerable extravascular passage was observed in subcutaneous tissue. The results indicate that in rat embryos the cerebral blood vessels are impermeable to albumin at least as early as the fifteenth day after fertilization. © 1968 Springer-Verlag.

引用

页码：117 / +

页数：1

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