CODEINE ANALGESIC AND MORPHINE HYPERALGESIC EFFECTS ON THERMAL NOCICEPTION IN DOMESTIC-FOWL

被引:24
作者
HUGHES, RA
机构
[1] Department of Psychology, Iowa State University, Ames
关键词
Analgesia; Analgesic drugs; Chickens; Codeine; Domestic fowl; Hyperalgesia; Hypoalgesia; Morphine; Naloxone; Narcotic antagonists; Narcotic drugs; Opiate; Opioid; Pain; Thermal nociception;
D O I
10.1016/0091-3057(90)90291-O
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of codeine phosphate and morphine sulfate (2.5, 15.0, and 30 mg/ml/kg;IM) on latency of a jump response elicited by a noxious (61°C) thermal stimulus were studied in White Leghorn cockerels at 15-16 days posthatch. Codeine induced a significant dose-dependent increase in jump response latency (analgesic effect), whereas morphine at each dose induced a significant decrease in jump response latency (hyperalgesic effect). Naloxone (5 mg/ml/kg) reversed the hyperalgesic effect of morphine (30 mg/ml/kg) and potentiated codeine analgesic effects. It is unlikely that codeine analgesic effects in domestic fowl reflect demethylation of codeine to morphine. These opposite codeine and morphine effects may reflect the interaction of these opiates at different populations of opioid receptors or at different substrates. © 1990.
引用
收藏
页码:567 / 570
页数:4
相关论文
共 31 条
[1]  
ALDER TK, 1952, J PHARMACOL EXP THER, V104, P1
[2]   SHOCK-ELICITED FLIGHT RESPONSE IN CHICKENS AS AN INDEX OF MORPHINE ANALGESIA [J].
BARDO, MT ;
HUGHES, RA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 9 (01) :147-149
[3]  
Bell DJ, 1984, PHYSL BIOCH DOMESTIC
[4]   THE IMPORTANCE OF 5-HYDROXYTRYPTAMINE TURNOVER FOR THE ANALGESIC EFFECT OF MORPHINE IN THE CHICKEN [J].
FAN, SG ;
SHUTT, AJ ;
VOGT, M .
NEUROSCIENCE, 1981, 6 (11) :2223-2227
[5]  
FINDLAY JWA, 1977, RES COMMUN CHEM PATH, V17, P595
[6]  
FINDLAY JWA, 1978, CLIN PHARMACOL THER, V24, P60
[7]   MORPHINE-INDUCED AND KETOCYCLAZOCINE-INDUCED ANALGESIA IN THE DEVELOPING RAT - DIFFERENCES DUE TO TYPE OF NOXIOUS STIMULUS AND BODY TOPOGRAPHY [J].
GIORDANO, J ;
BARR, GA .
DEVELOPMENTAL BRAIN RESEARCH, 1987, 32 (02) :247-253
[8]  
HUGHES RA, 1990, IN PRESS DEV PSYCHOB, V23
[9]   GENETIC MODULATIONS OF STRESS-INDUCED ANALGESIA IN MICE [J].
JACOB, JJ ;
NICOLA, MA ;
MICHAUD, G ;
VIDAL, C ;
PRUDHOMME, N .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 467 :104-115
[10]  
Jaffe J. H, 1985, PHARMACOL BASIS THER, P491