IS DIETARY ERGOTAMINE ATHEROGENIC IN THE RABBIT

被引：6

作者：

MEIJER, GW ^{[1
]}

JANSSEN, GB ^{[1
]}

BEYNEN, AC ^{[1
]}

SPEIJERS, GJA ^{[1
]}

机构：

[1] UNIV UTRECHT,DEPT LAB ANIM SCI,3508 TD UTRECHT,NETHERLANDS

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1992年 / 30卷 / 08期

关键词：

D O I：

10.1016/0278-6915(92)90171-G

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effect of dietary ergotamine on pre-lesional indicators of atherosclerosis was studied in rabbits. The experimental purified diets contained 0.08% (w/w) cholesterol and either 0, 40 or 200 mg ergotamine-tartrate/kg. After 6 wk, serum total cholesterol concentration and the ratio of serum total cholesterol:high-density lipoprotein-cholesterol were significantly increased by ergotamine in a dose-dependent manner. Dietary ergotamine raised the total level of glycosaminoglycans and the relative proportion of chondroitin sulphate in the abdominal aorta. It is suggested that dietary ergotamine is atherogenic in the rabbit.

引用

页码：731 / 734

页数：4

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