EMBRYONIC EXPRESSION AND FUNCTIONAL-ANALYSIS OF A XENOPUS ACTIVIN RECEPTOR

被引：63

作者：

HEMMATIBRIVANLOU, A ^{[1
]}

WRIGHT, DA ^{[1
]}

MELTON, DA ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT BIOCHEM & MOLEC BIOL,7 DIVIN AVE,CAMBRIDGE,MA 02138

来源：

DEVELOPMENTAL DYNAMICS | 1992年 / 194卷 / 01期

关键词：

ACTIVIN RECEPTOR; MESODERM INDUCTION; CNS; HINDBRAIN;

D O I：

10.1002/aja.1001940102

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

We report the isolation and characterization of a Xenopus activin receptor (XAR1). The amino acid sequence of this protein shows extensive homology with a murine activin receptor. The mRNA is expressed maternally and is ubiquitously distributed during the early stages of embryogenesis. Consistent with a possible role in mesoderm induction and patterning, interference with the normal expression of the receptor by overexpression in the early embryo results in the formation of ectopic dorsal axial structures. During neurulation the XAR1 mRNA is expressed predominantly in the presumptive brain and spinal cord, suggesting an additional function for XAR1 in neurogenesis.

引用

页码：1 / 11

页数：11

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