VASCULAR ADHESION MOLECULE EXPRESSION IN VIRAL CHRONIC HEPATITIS - EVIDENCE OF NEOANGIOGENESIS IN PORTAL TRACTS

被引：119

作者：

GARCIAMONZON, C

SANCHEZMADRID, F

GARCIABUEY, L

GARCIAARROYO, A

GARCIASANCHEZ, A

MORENOOTERO, R

机构：

[1] UNIV AUTONOMA MADRID,HOSP PRINCESA,DEPT IMMUNOL,E-28006 MADRID,SPAIN

[2] UNIV AUTONOMA MADRID,HOSP PRINCESA,PATHOL SERV,E-28006 MADRID,SPAIN

来源：

GASTROENTEROLOGY | 1995年 / 108卷 / 01期

关键词：

D O I：

10.1016/0016-5085(95)90029-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: T cell-mediated immune reactions could be crucial for hepatocellular damage in viral chronic hepatitis, The aims of this study were to compare the expression of activation and cell adhesion molecules on peripheral blood and intrahepatic lymphocytes from chronic hepatitis C and to analyze the intrahepatic expression of vascular adhesion molecules in viral chronic hepatitis, Methods: Lymphocytes from patients with chronic hepatitis C were studied by flow cytometry, intrahepatic expression of vascular adhesion molecules was assessed by immunohistochemistry. Results: Liver-derived T cells showed a high expression of activation and cell adhesion molecules, interestingly, we observed that vascular cell adhesion molecule 1 was up-regulated on both sinusoidal endothelial and portal dendritic cells. A novel finding was the neoformation of microvessels in inflamed portal tracts. An enhanced expression of endoglin was located on sinusoidal endothelial cells and on portal tracts. Conclusions: Activated cytotoxic T cells, which showed an upregulated expression of cell adhesion molecules, composed the majority of intrahepatic lymphocytes in chronic hepatitis C. The expression of vascular cell adhesion molecule 1 on portal dendritic cells and the microvessels neoformation in portal tracts from viral chronic hepatitis could define the main pathway for the recruitment and priming of liver-infiltrating T cells.

引用

页码：231 / 241

页数：11

共 72 条

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