ADVERSE REACTIONS TO DRUGS AS A CAUSE OF ADMISSIONS TO A GENERAL TEACHING HOSPITAL IN HONG-KONG

被引:37
作者
CHAN, TYK
CHAN, JCN
TOMLINSON, B
CRITCHLEY, JAJH
机构
[1] Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
关键词
D O I
10.2165/00002018-199207030-00008
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To determine the pattern of and the risk factors for adverse drug reactions (ADRs) in Hong Kong, a prospective study of acute admissions to 2 general medical wards at the Prince of Wales Hospital was undertaken. Of the 1701 admissions included in this study, 74 (4.4%) were attributed to ADRs. Sulphonylureas, nonsteroidal anti-inflammatories (NSAIDs) and insulin accounted for 61% of cases. The most frequent ADRs were hypoglycaemia (43%) and gastrointestinal haemorrhage (29.7%). Both old age and impaired renal function appear to be important risk factors for ADRs. In such situations, careful dose adjustment, use of an alternative drug or total avoidance may be necessary. Particular attention should be given to oral hypoglycaemic drugs and NSAIDs.
引用
收藏
页码:235 / 240
页数:6
相关论文
共 17 条
  • [1] Asplund K., Wilholm B.E., Lithner F., Glibenclamide-associated hypoglycaemia: a report on 57 cases, Diabetologia, 24, pp. 412-417, (1983)
  • [2] Berger W., Caduff F., Paquel M., Rump A., Die relative Haufigkeit der schweren Sulfonlharnstoff-Hypoglykamie in den letzten 25 Jahren in der Schweiz, Schweizerische Medizinische Wochenschrift, 116, pp. 145-151, (1986)
  • [3] Bergman U., Wiholm B.E., Drug-related problems causing admission to a medical clinic, European Journal of Clinical Pharmacology, 20, pp. 193-200, (1981)
  • [4] Caransos G.J., Stewart R.B., Cluff L.E., Drug-induced illness leading to hospitalisation, Journal of the American Medical Association, 228, pp. 713-717, (1974)
  • [5] Grymonpre R.E., Mitenko P.A., Sitar D.S., Aoki F.Y., Montgomery P.R., Drug-associated hospital admissions in older medical patients, Journal of the American Geriatrics Society, 36, pp. 1092-1098, (1988)
  • [6] Hawkey C.J., Non-steroidal anti-inflammatory drugs and peptic ulcers, British Medical Journal, 300, pp. 278-284, (1990)
  • [7] Holmberg L., Bottiger L.E., The drug-consuming patient and his drugs, Acta Medica Scandinavica, 213, pp. 211-216, (1983)
  • [8] Hurwitz N., Admissions to hospital due to drugs, British Medical Journal, 1, pp. 539-540, (1969)
  • [9] Karcn F.E., Lasagna L., Adverse drug reactions: a critical review, Journal of the American Medical Association, 234, pp. 1236-1241, (1975)
  • [10] Lam C.L.K., Tse M.H.W., Munro C., A study of the practice of self-medication in Hong Kong, Hong Kong Practitioner, 11, pp. 272-286, (1989)