THE FATE OF XO GERM-CELLS IN THE TESTES OF XO/XY AND XO/XY/XYY MOUSE MOSAICS - EVIDENCE FOR A SPERMATOGENESIS GENE ON THE MOUSE Y-CHROMOSOME

被引:43
作者
LEVY, ER
BURGOYNE, PS
机构
来源
CYTOGENETICS AND CELL GENETICS | 1986年 / 42卷 / 04期
关键词
D O I
10.1159/000132280
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A cytogenetic and histological study of nine XO/XY or XO/XY/XYY mosaic mice revealed that XO germ cells were selectively eliminated from the spermatogenic epithelium. Although the XO contribution to the bone marrow in seven mice exceeded 50%, in only two cases were significant numbers of dividing XO spermatogonia present. These XO germ cells only occasionally progressed to meiosis and then degenerated prior to first meiotic metaphase. It was concluded that the mouse Y chromosome carries a "spermatogenesis gene" (or genes) which acts autonomously in the germ cells.
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页码:208 / 213
页数:6
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