ABSORPTION OF AMOROLFINE THROUGH HUMAN NAIL

被引：26

作者：

FRANZ, TJ

机构：

[1] Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR

来源：

DERMATOLOGY | 1992年 / 184卷

关键词：

AMOROLFINE; NAIL; PERCUTANEOUS ABSORPTION; PHARMACOKINETICS;

D O I：

10.1159/000247611

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The percutaneous absorption of a new antifungal agent, amorolfine, has been measured through both skin and nail using an in vitro technique. Application of a 5% concentration in either an ethanol or methylene chloride lacquer resulted in permeation rates through nail in the range of 20-100 ng/cm2/h and somewhat higher through skin. Absorption was greater from the methylene chloride lacquer than the ethanol lacquer.

引用

页码：18 / 20

页数：3