BIOSYNTHESIS OF VITAMIN-B12 - USE OF A SINGLE C-13 LABEL IN THE MACROCYCLE TO CONFIRM C-11 METHYLATION IN PRECORRIN-6X

被引:16
作者
BLANCHE, F [1 ]
KODERA, M [1 ]
COUDER, M [1 ]
LEEPER, FJ [1 ]
THIBAUT, D [1 ]
BATTERSBY, AR [1 ]
机构
[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND
关键词
D O I
10.1039/c39920000138
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[11-C-13]Uro'gen III is unambiguously synthesised for enzymic conversion into precorrin-6x which as its octamethyl ester gives a 13C NMR spectrum confirming the presence of a C-11 methyl group.
引用
收藏
页码:138 / 139
页数:2
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