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REGIONAL ASSIGNMENT OF THE HUMAN HOMEOBOX-CONTAINING GENE-EN1 TO CHROMOSOME-2Q13-Q21

被引：12
作者：
KOHLER, A
LOGAN, C
JOYNER, AL
MUENKE, M
机构：
[1] UNIV PENN,DEPT PEDIAT,DIV HUMAN GENET & MOLEC BIOL,PHILADELPHIA,PA 19104
[2] UNIV TORONTO,DEPT MOLEC BIOL & MED GENET,TORONTO M5S 1A1,ONTARIO,CANADA
[3] MT SINAI HOSP,SAMUEL LUNENFELD RES INST,DIV MOLEC & DEV BIOL,TORONTO M5G 1X5,ONTARIO,CANADA
来源：
GENOMICS | 1993年 / 15卷 / 01期
关键词：
D O I：
10.1006/geno.1993.1045
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The human homeobox-containing genes EN1 and EN2 are closely related to the Drosophila pattern formation gene engrailed (en), which may be important in brain development, as shown by gene expression studies during mouse embryogenesis. Here, we have refined the localization of EN1 to human chromosome 2q13-q21 using a mapping panel of rodent/human cell hybrids containing different regions of chromosome 2 and a lymphoblastoid cell line with an interstitial deletion, del(2)(q21-q23.2). This regional assignment of EN1 increases to 22 the number of currently known genes on human chromosome 2q that have homologs on the proximal region of mouse chromosome 1. © 1993 Academic Press, Inc.
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页码：233 / 235
页数：3
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