AVALANCHES AND POWER-LAW BEHAVIOR IN LUNG-INFLATION

被引:216
作者
SUKI, B
BARABASI, AL
HANTOS, Z
PETAK, F
STANLEY, HE
机构
[1] BOSTON UNIV,CTR POLYMER STUDIES,BOSTON,MA 02215
[2] BOSTON UNIV,DEPT PHYS,BOSTON,MA 02215
[3] ALBERT SZENT GYORGYI MED UNIV,DEPT MED INFORMAT,SZEGED,HUNGARY
[4] ALBERT SZENT GYORGY MED UNIV,DEPT EXPTL SURG,SZEGED,HUNGARY
关键词
D O I
10.1038/368615a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
WHEN lungs are emptied during exhalation, peripheral airways close up1. For people with lung disease, they may not reopen for a significant portion of inhalation, impairing gas exchange2,3. A knowledge of the mechanisms that govern reinflation of collapsed regions of lungs is therefore central to the development of ventilation strategies for combating respiratory problems. Here we report measurements of the terminal airway resistance, R(t), during the opening of isolated dog lungs. When inflated by a constant flow, R(t) decreases in discrete jumps. We find that the probability distribution of the sizes of the jumps and of the time intervals between them exhibit power-law behaviour over two decades. We develop a model of the inflation process in which 'avalanches' of airway openings are seen-with power-law distributions of both the size of avalanches and the time intervals between them-which agree quantitatively with those seen experimentally, and are reminiscent of the power-law behaviour observed for self-organized critical systems4. Thus power-law distributions, arising from avalanches associated with threshold phenomena propagating down a branching tree structure, appear to govern the recruitment of terminal airspaces.
引用
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页码:615 / 618
页数:4
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