DISSOLUTION BEHAVIOR AND CHARACTERIZATION OF DIAZEPAM-PULLULAN COGROUND MIXTURES

被引：5

作者：

CHOUDHARI, KB ^{[1
]}

SANGHAVI, NM ^{[1
]}

机构：

[1] UNIV BOMBAY,DEPT CHEM TECHNOL,PHARMACEUT SECT,BOMBAY 400019,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 89卷 / 03期

关键词：

DISSOLUTION ENHANCEMENT; WATER-SOLUBLE CARRIER; COGRINDING; PULLULAN; DIAZEPAM; AMORPHIZATION;

D O I：

10.1016/0378-5173(93)90245-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to investigate the utilization of Pullulan as a water-soluble carrier to improve the in vitro dissolution rate of the poorly water-soluble drug diazepam. The coground mixtures of diazepam with Pullulan were characterized by spectrophotometric (infrared), thermal (DSC), powder X-ray diffractometry and in vitro dissolution techniques. The results indicated the prominent role of amorphization of crystalline drug in enhancing the in vitro dissolution rate. The effect of ageing on dissolution was also studied.

引用

页码：207 / 211

页数：5

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