THE AROMATIC HYDROCARBON RECEPTOR, DIOXIN ACTION, AND ENDOCRINE HOMEOSTASIS

被引：42

作者：

WHITLOCK, JP

机构：

[1] James P. Whitlock, Jr. is at the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 05期

关键词：

D O I：

10.1016/1043-2760(94)90075-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin acts through the aromatic hydrocarbon (AH) receptor to enhance CYP1A1 gene transcription. There are notable mechanistic analogies between dioxin action and lipophilic hormone action. In addition, some of dioxin's adverse effects ave associated with disruptions in endocrine homeostasis. Thus, dioxin biology intersects several disciplines, including toxicology, endocrinology, molecular biology, and public health.

引用

页码：183 / 188

页数：6

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