ADHESION MOLECULES AND STRUCTURAL PLASTICITY OF THE ADULT HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM

被引:35
作者
THEODOSIS, DT
BONFANTI, L
OLIVE, S
ROUGON, G
POULAIN, DA
机构
[1] UNIV TURIN,DIPARTIMENTO MORFOFISIOL VET,I-10124 TURIN,ITALY
[2] LAB GENET & PHYSIOL DEV,CNRS,UMR 9943,F-13288 MARSEILLE 9,FRANCE
关键词
NEURONAL PLASTICITY; OXYTOCIN; PSA-N-CAM; F3; GLYCOPROTEIN; TENASCIN; THY-1;
D O I
10.1016/0306-4530(94)90032-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The adult hypothalamo-neurohypophysial system, responsible for the secretion of the neurohormones, oxytocin, and vasopressin, undergoes reversible neuronal-glial and synaptic changes in response to stimulation (parturition, lactation, and osmotic stimulation). In the hypothalamus, these changes result in reduced astrocytic coverage of oxytocinergic somata and dendrites and concomitant increases in their GABAergic synapses; in the neurohypophysis, they lead to an enlarged neurovascular contact area. We discuss the possible role played by certain cell adhesion molecules, such as the highly sialylated isoform of the neural cell adhesion molecule, PSA-NCAM, the F3 glycoprotein, and the extracellular matrix molecule, tenascin, in such plasticity. The hypothalamo-neurohypophysial system continues to express high levels of these molecules during adulthood and they may serve as permissive factors to allow stimulus-induced structural remodelling to occur.
引用
收藏
页码:455 / 462
页数:8
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