FUNCTIONAL-SIGNIFICANCE OF 2 CYTOLYTIC PATHWAYS OF CYTOTOXIC T-LYMPHOCYTES

被引：43

作者：

PODACK, ER

机构：

[1] Department Microbiology/Immunology, University Miami School Medicine, Miami, FL

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1995年 / 57卷 / 04期

关键词：

CYTOTOXIC T LYMPHOCYTES; GRANULES; EXOCYTOSIS; APOPTOSIS; FAS; BCL2;

D O I：

10.1002/jlb.57.4.548

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cytotoxic lymphocytes are equipped with several effector molecules mediating cytotoxicity. Two pathways have been molecularly defined and functionally characterized through the analysis of deficiency states. It is evident from these results that lysis by granule exocytosis serves primarily to eliminate exogenous and endogenous hazards such as virally infected and transformed cells. In contrast, lysis by induced suicide in the fas pathway is used to maintain homeostasis of rapidly expanding and contracting cell populations including T cells.

引用

收藏

页码：548 / 552

页数：5

相关论文

共 50 条

[1] SPONTANEOUS MURINE LUPUS-LIKE SYNDROMES - CLINICAL AND IMMUNOPATHOLOGICAL MANIFESTATIONS IN SEVERAL STRAINS [J].

ANDREWS, BS ;

EISENBERG, RA ;

THEOFILOPOULOS, AN ;

IZUI, S ;

WILSON, CB ;

MCCONAHEY, PJ ;

MURPHY, ED ;

ROTHS, JB ;

DIXON, FJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 148 (05) :1198-1215

[2] SUPPRESSION OF APOPTOSIS IN A CYTOTOXIC T-CELL LINE BY INTERLEUKIN 2-MEDIATED GENE-TRANSCRIPTION AND DEREGULATED EXPRESSION OF THE PROTOONCOGENE BCL-2 [J].

DENG, G ;

PODACK, ER .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2189-2193

[3] CYTOLYSIS BY H-2-SPECIFIC-T KILLER CELLS - ASSEMBLY OF TUBULAR COMPLEXES ON TARGET MEMBRANES [J].

DENNERT, G ;

PODACK, ER .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 157 (05) :1483-1495

[4] Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin [J].

De Togni, Pietro ;

Goellner, Josphe ;

Ruddle, Nancy H. ;

Streeter, Philip R. ;

Fick, Andrea ;

Mariathasan, Sanjeev ;

Smith, Stacy C. ;

Carison, Rebecca ;

Shonnick, Laurie P. ;

strauss-Schoenberger, Jena ;

Russell, John H. ;

Karr, Robert ;

Chaplin, David D. .

JOURNAL OF IMMUNOLOGY, 2014, 192 (05) :2010-2014

[5]

DUKE RC, 1988, CYTOLYTIC LYMPHOCYTE, P35

[6] PERFORIN IS PRESENT ONLY IN NORMAL ACTIVATED LYT2+ LYMPHOCYTES-T AND NOT IN L3T4+ CELLS, BUT THE SERINE PROTEASE GRANZYME-A IS MADE BY BOTH SUBSETS [J].

GARCIASANZ, JA ;

PLAETINCK, G ;

VELOTTI, F ;

MASSON, D ;

TSCHOPP, J ;

MACDONALD, HR ;

NABHOLZ, M .

EMBO JOURNAL, 1987, 6 (04) :933-938

[7] CLONING OF A CDNA FOR A-T CELL-SPECIFIC SERINE PROTEASE FROM A CYTOTOXIC LYMPHOCYTE-T [J].

GERSHENFELD, HK ;

WEISSMAN, IL .

SCIENCE, 1986, 232 (4752) :854-858

[8] INDUCTION OF TARGET-CELL DNA RELEASE BY THE CYTO-TOXIC LYMPHOCYTE-T GRANULE PROTEASE GRANZYME-A [J].

HAYES, MP ;

BERREBI, GA ;

HENKART, PA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (03) :933-946

[9] MECHANISM OF LYMPHOCYTE-MEDIATED CYTO-TOXICITY [J].

HENKART, PA .

ANNUAL REVIEW OF IMMUNOLOGY, 1985, 3 :31-58

[10] CYTOTOXIC LYMPHOCYTES REQUIRE GRANZYME-B FOR THE RAPID INDUCTION OF DNA FRAGMENTATION AND APOPTOSIS IN ALLOGENEIC TARGET-CELLS [J].

HEUSEL, JW ;

WESSELSCHMIDT, RL ;

SHRESTA, S ;

RUSSELL, JH ;

LEY, TJ .

CELL, 1994, 76 (06) :977-987

← 1 2 3 4 5 →