HIV-1 PROTEASE INHIBITORS CONTAINING STATINE - INHIBITORY POTENCY AND ANTIVIRAL ACTIVITY

被引：13

作者：

FEHRENTZ, JA ^{[1
]}

CHOMIER, B ^{[1
]}

BIGNON, E ^{[1
]}

VENAUD, S ^{[1
]}

CHERMANN, JC ^{[1
]}

NISATO, D ^{[1
]}

机构：

[1] INSERM,U322,F-13273 MARSEILLE 9,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91136-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several series of chemically different inhibitors of the HIV-1 aspartyl protease have been described. Nevertheless despite the high in vitro potency showed, in most cases these inhibitors are unable to inhibit viral replication in infected cells. Penetration of the inhibitors across the cell membrane might account for their low antiviral activity. The relationship between inhibitory potency, antiviral activity and chemical structures of a series of oligopeptides containing statine or statine derivatives are presented here. © 1992.

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页码：865 / 872

页数：8

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