DESIGN OF ANTINEOPLASTIC AGENTS ON THE BASIS OF THE 2-PHENYLNAPHTHALENE-TYPE STRUCTURAL PATTERN .1. SYNTHESIS OF SUBSTITUTED 3-PHENYLQUINAZOLONES, BENZOXAZOLO[2,3-B]QUINAZOLONES AND BENZOTHIAZOLO[2,3-B]QUINAZOLONES

A number of substituted 3-phenylquinazolin-4-ones, 12H-benzoxazolo-[2,3-b]quniazolin-12-ones and 12H-benzothiazolo[2,3-b]quinazolin-12-ones were designed and synthesized on the basis of a ''2-phenylnaphthalene-type'' structural pattern hypothesis. The postulated pattern, which was uncovered among a substantial number of compounds of both natural and synthetic origins, was noted to be associated with compounds possessing a variety of biological properties which include the antineoplastic activity. Several compounds designed for the present study were found to exhibit potent cytotoxicity against the growth of human promyelocytic leukemia (HL-60) cells.